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Revealing a key protein behind heart disease
Atherosclerosis, caused by “bad cholesterol” (LDL), is the leading cause of global mortality. For decades, the structure of the central protein in LDL, apolipoprotein B100 (apoB100), remained elusive. AlphaFold 2 helped finally reveal its complex, cage-like shape. This long-awaited blueprint gives pharmaceutical researchers the atomic-level detail needed to design new preventative heart therapies.