Are Two LLMs Better Than One? A Student-Teacher Dual-Head LLMs Architecture for Pharmaceutical Content Optimization

arXiv:2602.11957v2 Announce Type: replace Abstract: Large Language Models (LLMs) are increasingly used for content creation in regulated domains such as pharmaceuticals, where content must be medical accurate and legally compliant. Traditional manual quality control (QC) is slow, error-prone, and create publication bottlenecks. To address this, we introduce a modular, LLM/VLMs-driven QC architecture, LRBTC (Language, Regulatory, Brand, Technical, Content Structure), implemented through a Student Teacher HITL architecture and Waterfall rule filtering logic for scalable, verifiable content validation. This architecture is designed to provide verifiable, traceable, and scalable content optimization. Our methods achieve 83.0% F1 and 97.5% recall on AIReg Bench, reducing missed violations five fold compared with Gemini 2.5 Pro. On CSpelling, it improves mean accuracy by +26.7 %. Our error analysis further reveals that while current models are strong at detecting misspellings (92.5% recall), they fail to identify complex grammatical (25.0% recall) and punctuation (41.7% recall) errors, highlighting a key area for future work. This work provides a practical, plug-and-play solution for reliable, transparent quality control of content in high-stakes, compliance-critical industries. We also provide demo access.